Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …
The role of astrocyte in neuroinflammation in traumatic brain injury
L He, R Zhang, M Yang, M Lu - … et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Traumatic brain injury (TBI), a significant contributor to mortality and morbidity worldwide, is
a devastating condition characterized by initial mechanical damage followed by subsequent …
a devastating condition characterized by initial mechanical damage followed by subsequent …
Treadmill exercise modulates intestinal microbes and suppresses LPS displacement to alleviate neuroinflammation in the brains of APP/PS1 mice
S Yuan, J Yang, Y Jian, Y Lei, S Yao, Z Hu, X Liu… - Nutrients, 2022 - mdpi.com
Neuroinflammation occurs throughout the pathogenesis of Alzheimer's disease (AD). Here,
we investigated the effects of treadmill exercise on neuroinflammation in APP/PS1 …
we investigated the effects of treadmill exercise on neuroinflammation in APP/PS1 …
Drug discovery and development targeting dementia
Dementia, most often associated with neurodegenerative diseases, affects millions of
people worldwide, predominantly the elderly. Unfortunately, no treatment is still available …
people worldwide, predominantly the elderly. Unfortunately, no treatment is still available …
Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet …
M Danielewski, A Gomułkiewicz, AZ Kucharska… - International Journal of …, 2023 - mdpi.com
Atherogenesis leads to the development of atherosclerosis, a progressive chronic disease
characterized by subendothelial lipoprotein retention and endothelial impairment in the …
characterized by subendothelial lipoprotein retention and endothelial impairment in the …
Borneol-Modified Schisandrin B Micelles Cross the Blood–Brain Barrier To Treat Alzheimer's Disease in Aged Mice
F Li, Y Yu, Y Du, L Kong, Y Liu, J Wang… - ACS Chemical …, 2024 - ACS Publications
Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that is
prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated that Sch …
prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated that Sch …
[HTML][HTML] Relationship between high-mobility group box-l and cognitive impairments induced by myocardial ischemia-reperfusion in elderly rats
W Yang, J Yu, H Wang, J He, R Pei - Experimental Gerontology, 2024 - Elsevier
Background Myocardial ischemia-reperfusion (MI/R) can lead to structural and functional
abnormalities in the hippocampal neurons of the brain. High-mobility group box-l (HMGB1) …
abnormalities in the hippocampal neurons of the brain. High-mobility group box-l (HMGB1) …
Cornuside protects against ischemic stroke in rats by suppressing the IL-17F/TRAF6/NF-κB pathway via the brain-gut axis
C Yan, Z Liu, W Xie, T Zhang, J Zhang, G Li, X Xu… - Experimental …, 2024 - Elsevier
Ischemic stroke is a serious neurological disease with limited therapeutic options; thus, it is
particularly important to find effective treatments. Restoration of gut microflora diversity is an …
particularly important to find effective treatments. Restoration of gut microflora diversity is an …
Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
X Fei, L Wang, Y Dou, F Fei, Y Zhang, W Lv… - Journal of …, 2024 - Springer
Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by
intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based …
intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based …
Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes
A Santiago-Balmaseda, A Aguirre-Orozco… - Cells, 2024 - mdpi.com
The astrocyte population, around 50% of human brain cells, plays a crucial role in
maintaining the overall health and functionality of the central nervous system (CNS) …
maintaining the overall health and functionality of the central nervous system (CNS) …