The family of interferon (IFN) proteins has now more than reached the potential envisioned
by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease
characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show …

A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated
transcription factors and opened chromatins to initiate transcription. However, it remains …

DNA damage, chromosomal abnormalities, oncogene activation, viral infection, substrate
detachment and hypoxia can all trigger apoptosis in normal cells. However, cancer cells …

Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer,
in addition to other human diseases including neurodegeneration, coronary disease and …

Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through …

Inhibitors of apoptosis (IAPs) are a family of proteins that regulate cell death and
inflammation. XIAP (X-linked IAP) is the only family member that suppresses apoptosis by …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

ABSTRACT XIAP-associated factor 1 (XAF1) is an interferon (IFN)-stimulated gene (ISG) that
enhances IFN-induced apoptosis. However, it is unexplored whether XAF1 is essential for …