Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular
energy status, and recent data demonstrate that it also plays a critical role in systemic …

The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Autophagy is an intracellular bulk degradation process for proteins and organelles. In the
heart, autophagy is stimulated by myocardial ischemia. However, the causative role of …

OBJECTIVE Autophagy is a critical cellular system for removal of aggregated proteins and
damaged organelles. Although dysregulated autophagy is implicated in the development of …