Association between financial incentives and participant deception about study eligibility
Importance Offers of payment for research participation are ubiquitous but may lead
prospective participants to deceive about eligibility, jeopardizing study integrity and …
prospective participants to deceive about eligibility, jeopardizing study integrity and …
Healthy volunteers in US phase I clinical trials: sociodemographic characteristics and participation over time
CA Kalbaugh, JM Kalbaugh, L McManus, JA Fisher - PLoS One, 2021 - journals.plos.org
Background Increasing the diversity of research participants is an important focus of clinical
trials. However, little is known regarding who enrolls as healthy volunteers in Phase I clinical …
trials. However, little is known regarding who enrolls as healthy volunteers in Phase I clinical …
Severe acute respiratory syndrome coronavirus 2 human challenge trials: too risky, too soon
To the Editor—Eyal et al [1] have recently argued that researchers should consider
conducting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human …
conducting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human …
Healthy volunteers' perceptions of the benefits of their participation in phase I clinical trials
Other than the financial motivations for enrolling in Phase I trials, research on how healthy
volunteers perceive the benefits of their trial participation is scant. Using qualitative …
volunteers perceive the benefits of their trial participation is scant. Using qualitative …
“Paid to endure”: Paid research participation, passivity, and the goods of work
E Malmqvist - The American Journal of Bioethics, 2019 - Taylor & Francis
A growing literature documents the existence of individuals who make a living by
participating in phase I clinical trials for money. Several scholars have noted that the …
participating in phase I clinical trials for money. Several scholars have noted that the …
The Ethics of Human Embryo Editing via CRISPR-Cas9 Technology: A Systematic Review of Ethical Arguments, Reasons, and Concerns
L Wiley, M Cheek, E LaFar, X Ma, J Sekowski… - HEC Forum, 2024 - Springer
The possibility of editing the genomes of human embryos has generated significant
discussion and interest as a matter of science and ethics. While it holds significant promise …
discussion and interest as a matter of science and ethics. While it holds significant promise …
The continued complexities of paying research participants
C Grady - The American Journal of Bioethics, 2019 - Taylor & Francis
Paying research participants is a widespread, long-standing, ethically acceptable, and
perennially fraught practice. Although data are limited, payment is offered to participants in …
perennially fraught practice. Although data are limited, payment is offered to participants in …
Ethical criteria for improved human subject protections in phase I healthy volunteer trials
Phase I healthy volunteer trials test the safety and tolerability of investigational
pharmaceuticals. In them, participants are exposed to study‐drug risks without the possibility …
pharmaceuticals. In them, participants are exposed to study‐drug risks without the possibility …
Qualitative study investigating the underlying motivations of healthy participants in phase I clinical trials
Objectives If patients are to reap the benefits of continued drug development, an
understanding of why healthy participants take part in phase I clinical trials is imperative …
understanding of why healthy participants take part in phase I clinical trials is imperative …
Feasibility of Using Population Pharmacokinetics‐Based Virtual Control Groups in Organ Impairment Studies
This work aimed to assess the feasibility of using population pharmacokinetics (popPK) to
generate virtual healthy control groups in organ impairment studies. Data from 11 organ …
generate virtual healthy control groups in organ impairment studies. Data from 11 organ …