[HTML][HTML] Measuring anxiety-like behaviors in rodent models of traumatic brain injury

LB Tucker, JT McCabe - Frontiers in behavioral neuroscience, 2021 - frontiersin.org
Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …

Epilepsy and its neurobehavioral comorbidities: insights gained from animal models

W Löscher, CE Stafstrom - Epilepsia, 2023 - Wiley Online Library
It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …

[HTML][HTML] Contusion brain damage in mice for modelling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal …

VM Golub, DS Reddy - Experimental Neurology, 2022 - Elsevier
Traumatic brain injury (TBI) is a leading cause of acquired epilepsy referred to as post-
traumatic epilepsy (PTE), characterized by spontaneous recurrent seizures (SRS) that start …

[HTML][HTML] ECoG spiking activity and signal dimension are early predictive measures of epileptogenesis in a translational mouse model of traumatic brain injury

R Di Sapia, M Rizzi, F Moro, I Lisi, A Caccamo… - Neurobiology of …, 2023 - Elsevier
The latency between traumatic brain injury (TBI) and the onset of epilepsy (PTE) represents
an opportunity for counteracting epileptogenesis. Antiepileptogenesis trials are hampered …

[HTML][HTML] Novel approaches to prevent epileptogenesis after traumatic brain injury

CG Dulla, A Pitkänen - Neurotherapeutics, 2021 - Elsevier
Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of
brain pathology caused by an external force. When epilepsy develops following TBI, it is …

[HTML][HTML] Convolutional neural networks enable robust automatic segmentation of the rat hippocampus in mri after traumatic brain injury

R De Feo, E Hämäläinen, E Manninen… - Frontiers in …, 2022 - frontiersin.org
Registration-based methods are commonly used in the automatic segmentation of magnetic
resonance (MR) brain images. However, these methods are not robust to the presence of …

Neocortical injury–induced status epilepticus

T Singh, S Joshi, JM Williamson, J Kapur - Epilepsia, 2020 - Wiley Online Library
Objective To characterize neocortical onset status epilepticus (SE) in the C57BL/6J mouse.
Methods We induced SE by administering homocysteine 16‐18 hours after cobalt (Co) …

[HTML][HTML] Plasma miR-9-3p and miR-136-3p as potential novel diagnostic biomarkers for experimental and human mild traumatic brain injury

S Das Gupta, R Ciszek, M Heiskanen… - International journal of …, 2021 - mdpi.com
Noninvasive, affordable circulating biomarkers for difficult-to-diagnose mild traumatic brain
injury (mTBI) are an unmet medical need. Although blood microRNA (miRNA) levels are …

[HTML][HTML] In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery

R Di Sapia, F Moro, M Montanarella, V Iori… - Acta Neuropathologica …, 2021 - Springer
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies and 10–20% of the acquired
forms. The latency between traumatic brain injury (TBI) and epilepsy onset in high-risk …

[HTML][HTML] Discovery and validation of circulating microRNAs as biomarkers for epileptogenesis after experimental traumatic brain injury–the EPITARGET cohort

M Heiskanen, S Das Gupta, JD Mills… - International journal of …, 2023 - mdpi.com
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies.
The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to …