The rifamycins1 belong to the family of ansamycin antibiotics, 3, 4 so named because of
their basket-like molecular architecture comprising an aromatic moiety bridged at …

Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The bacterial multienzyme polyketide synthases (PKSs) produce a diverse array of products
that have been developed into medicines, including antibiotics and anticancer agents. The …

Secondary metabolites are an important source of high-value chemicals, many of which
exhibit important pharmacological properties. These valuable natural products are often …

Abstract “There's life in the old dog yet!” This adage also holds true for natural product
research. After the era of natural products was declared to be over, because of the …

Nonribosomal peptides (NRPs) are a class of microbial secondary metabolites that have a
wide variety of medicinally important biological activities, such as antibiotic (vancomycin) …

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways -
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …

Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …

Covering: 1990 to 2010 Heterologous biosynthesis has emerged as a viable route to access
the beneficial properties of natural products. This development primarily owes to the …