Antimicrobial peptides: An overview of their structure, function and mechanism of action

R Zhang, L Xu, C Dong - Protein and Peptide Letters, 2022 - ingentaconnect.com
In recent years, the antibiotic resistance of pathogenic bacteria has become an increasing
public health threat. Finding alternatives to antibiotics may be an effective solution to the …

[HTML][HTML] Emerging peptide antibiotics with therapeutic potential

G Upert, A Luther, D Obrecht, P Ermert - Medicine in drug discovery, 2021 - Elsevier
This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

Thanatin: an emerging host defense antimicrobial peptide with multiple modes of action

R Dash, S Bhattacharjya - International journal of molecular sciences, 2021 - mdpi.com
Antimicrobial peptides (AMPs) possess great potential for combating drug-resistant bacteria.
Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP which was …

Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides

S Bhattacharjya, SA Mohid, A Bhunia - International Journal of Molecular …, 2022 - mdpi.com
Global rise of infections and deaths caused by drug-resistant bacterial pathogens are
among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat …

[HTML][HTML] Linking dual mode of action of host defense antimicrobial peptide thanatin: Structures, lipopolysaccharide and LptAm binding of designed analogs

S Sinha, VB Dhanabal, P Sperandeo, A Polissi… - … et Biophysica Acta (BBA …, 2022 - Elsevier
At present, antibiotics options to cure infections caused by drug resistant Gram-negative
pathogens are highly inadequate. LPS outer membrane, proteins involved in LPS transport …

Outer-Membrane Permeabilization, LPS Transport Inhibition: Activity, Interactions, and Structures of Thanatin Derived Antimicrobial Peptides

SJ Abdullah, BTS Yan, N Palanivelu… - International Journal of …, 2024 - mdpi.com
Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-
negative bacteria are highly limited. Thanatin, a 21-residue-long insect-derived antimicrobial …

[HTML][HTML] Targeting the LPS export pathway for the development of novel therapeutics

P Sperandeo, AM Martorana, M Zaccaria… - Biochimica et Biophysica …, 2023 - Elsevier
The rapid rise of multi-resistant bacteria is a global health threat. This is especially serious
for Gram-negative bacteria in which the impermeable outer membrane (OM) acts as a shield …

[HTML][HTML] DPPA as a potential cell membrane component responsible for binding Amyloidogenic protein human cystatin C

I Zhukov, E Sikorska, M Orlikowska… - Molecules, 2024 - mdpi.com
A phospholipid bilayer is a typical structure that serves crucial functions in various cells and
organelles. However, it is not unusual for it to take part in pathological processes. The cell …

The synergy of thanatin and cathelicidin-BF-15a3 combats Escherichia coli O157: H7

X Xia, S Song, S Zhang, W Wang, J Zhou, B Fan… - International Journal of …, 2023 - Elsevier
Escherichia coli O157: H7 is a pathogen that commonly causes foodborne illness and
represents a health hazard to consumers. The combined use of synergistic antimicrobial …

Monitoring the interactions between POPG phospholipid bilayer and amyloid-forming protein human cystatin C. Does the bilayer influence the oligomeric state and …

P Jurczak, I Zhukov, M Orlikowska… - … et Biophysica Acta (BBA …, 2024 - Elsevier
A biological membrane is a structure characteristic for various cells and organelles present
in almost all living organisms. Even though, it is one of the most common structures in …