Animal models have been extensively used in cancer pathology studies and drug discovery.
These models, however, fail to reflect the complex human tumor microenvironment and do …

Background Cuproptosis induced by FDX1 is a newly discovered mechanism regulating cell
death. However, the role of FDX1 in the pathogenesis of colon adenocarcinoma (COAD) …

Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …

Abstract Introduction The inhibition of Hedgehog (Hh) signaling in pancreatic ductal
adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In …

Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors.
Endoplasmic reticulum stress (ERS) plays an essential role in PDAC progression. Here, we …

Despite the tremendous clinical successes recorded in the landscape of cancer therapy,
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …

The purpose of this study was to investigate the expression significance, predictive value,
immunologic function, and biological role of transmembrane protein 158 (TMEM158) in the …

In this chapter, we provide information about metabolic reprogramming in cancer cells,
molecular interactions between tumor and stromal cells in the tumor microenvironment …

Pancreatic cancer is an aggressive disease with a 5 year survival rate of 13%. This poor
survival is attributed, in part, to limited and ineffective treatments for patients with metastatic …

Advances in surgery, peri-operative care and systemic chemotherapy have not significantly
improved the prognosis of pancreatic cancer for several decades. Early clinical trials of …