Endothelial dysfunction and immunothrombosis in sepsis

E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

[HTML][HTML] Anticoagulant therapy for sepsis‐associated disseminated intravascular coagulation: the view from Japan

T Iba, S Gando, J Thachil - Journal of Thrombosis and Haemostasis, 2014 - Elsevier
The current management of disseminated intravascular coagulation (DIC) is based on
aggressive treatment of the underlying condition and resuscitation with appropriate blood …

Protein C and acute inflammation: a clinical and biological perspective

SC Christiaans, BM Wagener… - American Journal of …, 2013 - journals.physiology.org
The protein C system plays an active role in modulating severe systemic inflammatory
processes such as sepsis, trauma, and acute respiratory distress syndrome (ARDS) via its …

Evolution and impact of thrombocytopenia in septic shock: a retrospective cohort study

CE Menard, A Kumar, DS Houston… - Critical care …, 2019 - journals.lww.com
Objectives: To characterize the prevalence, incidence, and temporal evolution of
thrombocytopenia (platelets< 100× 10 9/L) in septic shock and to investigate the …

[HTML][HTML] Anticoagulant modulation of inflammation in severe sepsis

KS Allen, E Sawheny, GT Kinasewitz - World journal of critical care …, 2015 - ncbi.nlm.nih.gov
Inflammation and coagulation are so tightly linked that the cytokine storm which
accompanies the development of sepsis initiates thrombin activation and the development of …

White blood cell count trajectory and mortality in septic shock: A historical cohort study

E Rimmer, A Garland, A Kumar, S Doucette… - Canadian Journal of …, 2022 - Springer
Purpose Septic shock is associated with a mortality of 20–40%. The white blood cell count
(WBC) at hospital admission correlates with prognosis in septic shock. Here, we explore …

[PDF][PDF] 脓毒性休克患者降钙素原的变化规律及其与预后的关系

黄伟平, 黄澄, 温妙云, 江稳强, 曾红科 - 中华危重病急救医学, 2013 - cccm-em120.com
目的探讨脓毒性休克患者降钙素原(PCT) 的变化规律及其与预后的关系. 方法选取本院符合脓
毒性休克诊断的63 例患者, 于入住重症监护病房(ICU) 1, 3, 5, 7+ d 检测PCT, C-反应蛋白(CRP) …

The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome

A Donati, E Damiani, L Botticelli, E Adrario… - BMC …, 2013 - Springer
Background The role of recombinant activated protein C (aPC) during sepsis is still
controversial. It showed anti-inflammatory effect and improved the microvascular perfusion …

Antithrombin III and D-dimer levels as indicators of disease severity in patients with hyperlipidaemic or biliary acute pancreatitis

N Yang, J Hao, D Zhang - Journal of International Medical …, 2017 - journals.sagepub.com
Objective To assess changes in anticoagulation and fibrinolytic systems between biliary and
hyperlipidaemic acute pancreatitis (AP). Methods Patients with biliary or hyperlipidaemic AP …

Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside

A Donati, D Tibboel, C Ince - Critical care, 2013 - Springer
Current hemodynamic monitoring of critically ill patients is mainly focused on monitoring of
pressure-derived hemodynamic variables related to systemic circulation. Increasingly …