Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable
hematological malignancy that affects the myeloid cell progenies and challenges patients of …

Hematopoietic stem-cell transplantation, which is used to treat both malignant and
nonmalignant conditions, was first conceived more than 50 years ago, but problems …

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

The ability of allogeneic bone-marrow cells and peripheral-blood stem cells to cure
leukaemia remains the most striking example of the ability of the human immune system to …

Although the immune system has long been implicated in the control of cancer, evidence for
specific and efficacious immune responses in human cancer has been lacking. In the case …

The graft-versus-tumour effect seen after allogeneic (genetically different) haematopoietic
cell transplantation for human malignancies represents the clearest example of the power of …

Chronic myelogenous leukemia is a myeloproliferative disorder. It is characterized by a
biphasic or triphasic clinical course in which a benign chronic phase is followed by …

Despite high response rates after initial chemotherapy in patients with acute myeloid
leukemia (AML), relapses occur frequently, resulting in a five-year-survival by< 30% of the …

We describe the safety and immunogenicity of a combined vaccine of 2 leukemia-associated
antigenic peptides, PR1 and WT1. Eight patients with myeloid malignancies received one …

Hematologic malignancies such as acute and chronic myeloid leukemia are characterized
by the malignant transformation of immature CD34+ progenitor cells. Transformation is …