Structural insights of metallo-beta-lactamase revealed an effective way of inhibition of enzyme by natural inhibitors

BS Gangadharappa, R Sharath… - Journal of …, 2020 - Taylor & Francis
Abstract Metallo-beta-lactamase (MBL) is a class of enzyme that catalyzes the hydrolysis of
a broad range of beta-lactam antibiotics leading to the development of drug resistance in …

Formulation and evaluation of rutin-loaded solid lipid nanoparticles for the treatment of brain tumor

SRK Pandian, P Pavadai, S Vellaisamy… - Naunyn-Schmiedeberg's …, 2021 - Springer
The primary requirement for curing cancer is the delivery of essential drug load at the cancer
microenvironment with therapeutic efficacy. Considering this, the present study aims to …

Evaluating Andrographolide as a Potent Inhibitor of NS3‐4A Protease and Its Drug‐Resistant Mutants Using In Silico Approaches

V Chandramohan, A Kaphle, M Chekuri… - Advances in …, 2015 - Wiley Online Library
Current combination therapy of PEG‐INF and ribavirin against the Hepatitis C Virus (HCV)
genotype‐1 infections is ineffective in maintaining sustained viral response in 50% of the …

[HTML][HTML] Bioactive phenolic fraction of Citrus maxima abate lipopolysaccharide-induced sickness behaviour and anorexia in mice: In-silico molecular docking and …

R Nandeesh, S Vijayakumar, A Munnolli… - Biomedicine & …, 2018 - Elsevier
Sickness behaviour, fever, anxiety, anorexia and depression are interrelated phenomena.
The citrus fruit peels offering significant low-cost nutritional dietary supplements due to its …

Targeting Imd pathway receptor in Drosophila melanogaster and repurposing of phyto-inhibitors: structural modulation and molecular dynamics

P Satapathy, JK Prakash, VC Gowda… - Journal of …, 2022 - Taylor & Francis
Dysbiosis is a major cause of disease in an individual, generally initiated in the
gastrointestinal tract. The gut, also known as the second brain, constitutes a major role in …

[HTML][HTML] Molecular Docking used as an advanced tool to determine novel compounds on emerging infectious diseases: A systematic review

K Gouthami, V Veeraraghavan, GD Saratale, A Rahdar… - 2021 - europepmc.org
Emerging infectious diseases (EIDs) are among the major problems impacted on global
economics and healthful living. EIDs have long been perceive as a predominant conclusion …

Identification of Plant-Based Bio-Actives in the Treatment of Ulcerative Colitis Using Virtual Screening and In Vivo Approaches

M Dammalli, BS Gangadharappa… - Proceedings of the …, 2024 - Springer
Ulcerative colitis (UC) is a kind of persistent inflammatory bowel disease that is a root cause
for lifelong soreness in the colon and rectum inflammation. Nuclear transcription factor …

Identification of potential inhibitors of ATM kinase: pharmacoinformatics and molecular dynamics simulation approach

C Inchara Moodbagil, R Mahmood… - Molecular …, 2023 - Taylor & Francis
ABSTRACT Ataxia-Telangiectasia Mutated kinase (ATM kinase) is a well-established
protein, maintains genome integrity and modulates cellular responses to DNA breakage. It is …

[PDF][PDF] Synthesis of Nα-protected aminoacid/peptide Weinreb amides employing N,N'-carbonyldiimidazole as activating agent; studies on docking and antibacterial …

K Uma, HS Lalithamba, M Raghavendra… - … : Online Journal of …, 2016 - researchgate.net
An efficient method for the synthesis of Nα-protected amino/peptide Weinreb amides(N-
methoxy-N-methylamides) employing N, N'-carbonyldiimidazole (CDI) has been achieved …

[HTML][HTML] Structural modulation of dual oxidase (Duox) in Drosophila melanogaster by phyto-elicitors: A free energy study with molecular dynamics approach

P Satapathy, JK Prakash, SS More… - Informatics in Medicine …, 2021 - Elsevier
The gut, as a paradigm is considered to be the second brain, plays a pivotal role in
maintaining a healthy metabolism and negatively modulates dysbiosis at both the micro and …