FMRP-driven neuropathology in autistic spectrum disorder and alzheimer's disease: a losing game

L Bleuzé, V Triaca, A Borreca - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Fragile X mental retardation protein (FMRP) is an RNA binding protein (RBP) whose
absence is essentially associated to Fragile X Syndrome (FXS). As an RNA Binding Protein …

An “omic” overview of fragile X syndrome

O Dionne, F Corbin - Biology, 2021 - mdpi.com
Simple Summary Fragile X syndrome (FXS) is a neurodevelopmental disorder and remains
the most frequent inherited cause of intellectual disability. Fragile X patients are at great risk …

Changes in neuroimmune and neuronal death markers after adolescent alcohol exposure in rats are reversed by donepezil

HS Swartzwelder, KL Healey, W Liu, K Dubester… - Scientific reports, 2019 - nature.com
Adolescent intermittent ethanol (AIE) exposure diminishes neurogenesis and dendritic spine
density in the dentate gyrus. The cholinesterase inhibitor, donepezil (Aricept), reverses AIE …

Dysregulation of the mTOR-FMRP pathway and synaptic plasticity in an environmental model of ASD

ML Hilal, E Rosina, G Pedini, L Restivo, C Bagni - Molecular Psychiatry, 2024 - nature.com
Abstract Autism Spectrum Disorder (ASD) is caused by genetic, epigenetic, and
environmental factors. Mutations in the human FMR1 gene, encoding the Fragile X …

[HTML][HTML] The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture …

L Matelski, KPK Stietz, S Sethi, SL Taylor… - Current research in …, 2020 - Elsevier
Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants implicated as
risk factors for neurodevelopmental disorders (NDDs). Immune dysregulation is another …

FXTAS presents with upregulation of the cytokines IL12 and TNFα

BD Dufour, S Amina, V Martinez-Cerdeno - Parkinsonism & related …, 2021 - Elsevier
Abstract Introduction Fragile X Tremor and Ataxia Syndrome is a progressive
neurodegenerative disorder that develops in some FMR1 premutation carriers. The …

Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome

SL Hodges, SO Nolan, LA Tomac, IDA Muhammad… - Physiology & …, 2020 - Elsevier
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a single genetic
mutation in the Fmr1 gene, serving as the largest genetic cause of intellectual disability …

[HTML][HTML] FMR1 is identified as an immune-related novel prognostic biomarker for renal clear cell carcinoma: A bioinformatics analysis of TAZ/YAP

S Wu, H He, J Huang, S Jiang, X Deng… - Mathematical …, 2022 - aimspress.com
WW domain-containing transcription regulator 1 (TAZ, or WWTR1) and Yes-associated
protein 1 (YAP) are both important effectors of the Hippo pathway and exhibit different …

Fragile X mental retardation protein‐regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by …

Y Yang, J Zhao, Y Li, X Li, X Chen… - Journal of …, 2021 - Wiley Online Library
Studies have verified that Fragile X mental retardation protein (FMRP), an RNA‐binding
protein, plays a potential role in the pathogenesis of formalin‐and (RS)‐3, 5 …

[HTML][HTML] Altered inflammatory response in FMRP-deficient microglia

JM Parrott, T Oster, HY Lee - Iscience, 2021 - cell.com
Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid
autism spectrum disorders. Since FXS is a genetic disease, patients are more susceptible to …