Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …
pathophysiological processes in the atria. Some aspects of the morphological and …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
[HTML][HTML] Recent advances in the molecular pathophysiology of atrial fibrillation
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
Atrial remodeling and atrial fibrillation: mechanisms and implications
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …
age but is very rare in children and becomes extremely common in the elderly, with a …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
New antiarrhythmic drugs for treatment of atrial fibrillation
Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …
The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …
increasing with the ageing of the population. Presently available treatment options are far …
[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions
J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …
general population. It is characterized by rapid and disorganized atrial activation leading to …
Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation
N Voigt, A Trausch, M Knaut, K Matschke… - Circulation …, 2010 - Am Heart Assoc
Background—Recent evidence suggests that atrial fibrillation (AF) is maintained by high-
frequency reentrant sources with a left-to-right–dominant frequency gradient, particularly in …
frequency reentrant sources with a left-to-right–dominant frequency gradient, particularly in …