The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Data mining of available biomedical data and information has greatly boosted target
discovery in the 'omics' era. Target discovery is the key step in the biomarker and drug …

Purpose To establish whether the association between milk intake and prostate cancer
operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1 …

Background: Amitriptyline has been replaced in many countries by alternative and more
expensive drugs based on claims of improved tolerability and toxicity and despite slightly …

BACKGROUND Prostate cancer is the most common cancer diagnosis in men and a leading
cause of death. Improvements in disease management would have a significant impact and …

Carotenoids are of great interest due to their essential biological functions in both plants and
animals. However, the properties and functions of carotenoids in natural systems are …

Cisplatin-based chemotherapy is the paradigm of non-small-cell lung cancer (NSCLC)
treatment; however, it also induces de novo DNA-hypermethylation, a process that may be …

During cancer development and progression, tumor cells undergo abnormal epigenetic
modifications, including DNA methylation, histone deacetylation and nucleosome …

It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1
(105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to …

Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the
biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in …