Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

The survival benefit derived from sorafenib treatment for patients with hepatocellular
carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the
adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

The molecular and genetic subtyping of cancer has allowed the emergence of individualized
therapies. This approach could potentially deliver treatments that have both increased …

Serrated colorectal carcinomas (CRCs) are morphologically different from conventional
CRCs and have been proposed to follow a distinct pathway of CRC formation. Despite …