New and current clinical imaging techniques to study chronic obstructive pulmonary disease

HO Coxson, J Mayo, S Lam, G Santyr… - American journal of …, 2009 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized
by both small airway and parenchymal abnormalities. There is increasing evidence to …

Hyperpolarized 3He and 129Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease

M Kirby, S Svenningsen, A Owrangi, A Wheatley… - Radiology, 2012 - pubs.rsna.org
Purpose To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe)
magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and …

Quantitative pulmonary imaging using computed tomography and magnetic resonance imaging

GR Washko, G Parraga, HO Coxson - Respirology, 2012 - Wiley Online Library
Measurements of lung function, including spirometry and body plethesmography, are easy
to perform and are the current clinical standard for assessing disease severity. However …

Diffusion‐weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease

SS Kaushik, ZI Cleveland, GP Cofer… - Magnetic …, 2011 - Wiley Online Library
Given its greater availability and lower cost, 129Xe apparent diffusion coefficient (ADC) MRI
offers an alternative to 3He ADC MRI. To demonstrate the feasibility of hyperpolarized …

Chronic Obstructive Pulmonary Disease: Longitudinal Hyperpolarized 3He MR Imaging

M Kirby, L Mathew, A Wheatley, GE Santyr… - Radiology, 2010 - pubs.rsna.org
Purpose To quantitatively evaluate a small pilot group of ex-smokers with chronic obstructive
pulmonary disease (COPD) and healthy volunteers during approximately 2 years by using …

Hyperpolarized 3He magnetic resonance imaging: comparison with four-dimensional x-ray computed tomography imaging in lung cancer

L Mathew, A Wheatley, R Castillo, E Castillo… - Academic radiology, 2012 - Elsevier
RATIONALE AND OBJECTIVES: Pulmonary functional imaging using four-dimensional x-ray
computed tomographic (4DCT) imaging and hyperpolarized 3He magnetic resonance …

Hyperpolarized xenon‐129 gas‐exchange imaging of lung microstructure: first case studies in subjects with obstructive lung disease

I Dregely, JP Mugler III, IC Ruset… - Journal of magnetic …, 2011 - Wiley Online Library
Purpose: To develop and test a method to noninvasively assess the functional lung
microstructure. Materials and Methods: The Multiple exchange time Xenon polarization …

On the role of abnormal DLCO in ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI

M Kirby, A Owrangi, S Svenningsen, A Wheatley… - Thorax, 2013 - thorax.bmj.com
Background The functional effects of abnormal diffusing capacity for carbon monoxide
(DLCO) in ex-smokers without chronic obstructive pulmonary disease (COPD) are not well …

Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease

A Ouriadov, A Farag, M Kirby… - Magnetic resonance …, 2013 - Wiley Online Library
Purpose The goal of this work was to investigate lung morphological changes associated
with chronic obstructive pulmonary disease (COPD) using hyperpolarized 129Xe diffusion …

Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease

Y Shukla, A Wheatley, M Kirby, S Svenningsen… - Academic radiology, 2012 - Elsevier
RATIONALE AND OBJECTIVES: The objective of this study was to evaluate the tolerability of
hyperpolarized 129Xe gas inhaled from functional residual capacity and magnetic …