Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives
A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …
compound with wide ranges of pharmacological activities due to different mechanisms of …
Chalcone: a privileged structure in medicinal chemistry
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
Recent progress in biological activities of indole and indole alkaloids
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Chalcone: A promising bioactive scaffold in medicinal chemistry
G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
[HTML][HTML] Diverse molecular targets for chalcones with varied bioactivities
B Zhou, C Xing - Medicinal chemistry, 2015 - ncbi.nlm.nih.gov
Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …
biological activities that may benefit human health. The underlying mechanisms of action …
Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives
Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities
Abstract Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …
Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …