To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

Eph receptor tyrosine kinases play critical functions during development, in the formation of
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …

During neural circuit assembly, axonal growth cones are exposed to multiple guidance
signals at trajectory choice points. While axonal responses to individual guidance cues have …

Synapses are specialized cell-cell junctions that underlie the function of neural circuits by
mediating communication between neurons. Both the formation and function of synapses …

Highlights•Structure–function analyses of multimerisation and ligand specific-function of Eph
receptors.•Insights into modalities of ephrin: Eph signalling and its intersection with other …

In vertebrates, the Eph/ephrin family of signaling molecules is a large group of membrane-
bound proteins that signal through a myriad of mechanisms and effectors to play diverse …

Engineered analog-sensitive (AS) protein kinases have emerged as powerful tools for
dissecting phospho-signaling pathways, for elucidating the cellular function of individual …

Dendritic filopodia select synaptic partner axons by interviewing the cell surface of potential
targets, but how filopodia decipher the complex pattern of adhesive and repulsive molecular …

Cell segregation is the process by which cells self-organize to establish developmental
boundaries, an essential step in tissue formation. Cell segregation is a common outcome of …