In the heart, Ca2+ influx via CaV1. 2 L-type calcium channels (LTCCs) is a multi-functional
signal that triggers muscle contraction, controls action potential duration, and regulates gene …

MicroRNAs (miRNAs) are emerging as key control molecules in the regulation of gene
expression, and their role in heart disease is becoming increasingly evident. Given the …

Electrical remodeling of the heart takes place in response to both functional (altered
electrical activation) and structural (including heart failure and myocardial infarction) …

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the
principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood …

Narrow, tubular, inward projections of the sarcolemma ('T-tubules') are an established
feature of adult mammalian ventricular myocytes that enables them to generate the whole …

Heart rhythm disorders, arrhythmias, place a huge economic burden on society and have a
large impact on the quality of life of a vast number of people. Arrhythmias can have genetic …

Coronary artery disease is the leading cause of death in the developed world and in
developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in …

Abstract sarco–endoplasmic reticulum Ca‐ATPase (SERCA) is the major transporter present
in sarco–endoplasmic reticulum (SR/ER), transporting calcium back into SR/ER from cytosol …

Spatial and temporal control of calcium (Ca 2+) levels is essential for the background
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …

The search for alternative anti-arrhythmic strategies is fueled by an unmet medical need as
well as by the opportunities arising from identification of novel targets and novel drugs …