The role of nitric oxide (NO•) as a mediator of cancer phenotype has led researchers to
investigate strategies for manipulating in vivo production and exogenous delivery of this …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors
and NO delivery systems in anticancer therapy, the limited understanding of exogenous …

The formation of quinone methides (QMs) from either direct 2-electron oxidation of 2-or 4-
alkylphenols, isomerization of oquinones, or elimination of a good leaving group could …

The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …

A series of NO-donor praziquantel hybrid compounds was obtained by combining
praziquantel (PZQ) and furoxan moieties in a single entity. NO-donor properties of the …

Background Nitric oxide (NO) has been heavily implicated in migraine. Nitroglycerin is a
prototypic NO-donor, and triggers migraine in humans. However, nitroglycerin also induces …

Introduction: There is a great interest in Nitric oxide (NO) within medicinal chemistry since it's
involved in human signaling pathways. Prodrugs or hybrid compounds containing NO-donor …

The liver is an important organ of the body, which has a vital role in metabolic functions. The
non‐steroidal anti‐inflammatory drug (NSAID), diclofenac causes hepato‐renal toxicity and …

Many types of cancers, including endometrial cancer, were found to have cyclooxygenase-2
(COX-2) overexpression. Because this enzyme belongs to the group of pro-inflammatory …