Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

M Adamaki, V Zoumpourlis - Pharmacology & therapeutics, 2021 - Elsevier
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

[HTML][HTML] Binding of S100 proteins to RAGE: an update

E Leclerc, G Fritz, SW Vetter, CW Heizmann - Biochimica et Biophysica …, 2009 - Elsevier
The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the
immunoglobulin family. RAGE interacts with structurally different ligands probably through …

The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity

MT Lotze, HJ Zeh, A Rubartelli… - Immunological …, 2007 - Wiley Online Library
The response to pathogens and damage in plants and animals involves a series of carefully
orchestrated, highly evolved, molecular mechanisms resulting in pathogen resistance and …

Damage-associated molecular patterns in cancer: a double-edged sword

C Hernandez, P Huebener, RF Schwabe - Oncogene, 2016 - nature.com
Damage-associated molecular patterns (DAMPs) are released in response to cell death and
stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs …

[HTML][HTML] Current status of biomarkers for prostate cancer

VM Velonas, HH Woo, CG dos Remedios… - International journal of …, 2013 - mdpi.com
Prostate cancer (PCa) is a leading cause of cancer-related death of men globally. Since its
introduction, there has been intense debate as to the effectiveness of the prostate specific …

[HTML][HTML] S100A4 in cancer progression and metastasis: A systematic review

F Fei, J Qu, M Zhang, Y Li, S Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Metastasis is the leading cause of cancer-related death and directly associates with cancer
progression, resistance to anticancer therapy, and poor patient survival. Current efforts …

A review of the S100 proteins in cancer

I Salama, PS Malone, F Mihaimeed, JL Jones - European Journal of …, 2008 - Elsevier
AIM: In the quest to reduce mortality and morbidity from cancer, there is continued effort to
identify novel biomarkers to aid in the early detection and the accurate prediction of tumour …

[HTML][HTML] Molecular characteristics of RAGE and advances in small-molecule inhibitors

HJ Kim, MS Jeong, SB Jang - International journal of molecular sciences, 2021 - mdpi.com
Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …

[HTML][HTML] S100A4, a mediator of metastasis

SC Garrett, KM Varney, DJ Weber… - Journal of Biological …, 2006 - ASBMB
The transition from benign tumor growth to malignancy is manifested by the ability of tumor
cells to traverse tissue barriers and invade surrounding tissues. The traversal of basement …

S100A8 and S100A9 activate MAP kinase and NF-κB signaling pathways and trigger translocation of RAGE in human prostate cancer cells

A Hermani, B De Servi, S Medunjanin… - Experimental cell …, 2006 - Elsevier
S100 proteins, a multigenic family of calcium-binding proteins, have been linked to human
pathologies in recent years. Deregulated expression of S100 proteins, including S100A8 …