Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Background: The rise in nutrition-related morbidity and mortality requires public health
intervention programs targeting nutritional behavior. In addition to socio-economical, socio …

The chemical senses (smell and taste) have evolved complex repertoires of chemosensory
receptors—G-protein coupled receptors with a seven-transmembrane domain structure. In …

In the past several years, tremendous progress has been achieved with the discovery and
characterization of vertebrate taste receptors from the T1R and T2R families, which are …

Scope To avoid ingestion of potentially harmful substances, humans are equipped with
about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit …

Vertebrate Tas2r taste receptors bind to bitter compounds, which are typically poisonous, to
elicit bitter sensation to prevent the ingestion of toxins. Previous studies noted a marked …

The recent advances in the functional expression of TAS2Rs in heterologous systems
resulted in the identification of bitter tastants that specifically activate receptors of this family …

A family of approximately 30 TAS2R bitter taste receptors has been identified in mammals.
Their genes evolved through adaptive diversification and are linked to chromosomal loci …

Exponential growth in the number of patients suffering from diseases caused by the
consumption of sugar has become a threat to mankind's health. Artificial low calorie …