After more than 50 years of intensive research and development, only one malaria vaccine
candidate,“RTS, S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy …

Protein-protein interactions (IPP) play an essential role in practically all biological
processes, including those related to microorganism invasion of their host cells. It has been …

Plasmodium parasites use specialized ligands which bind to red blood cell (RBC) receptors
during invasion. Defining the mechanism of receptor recognition is essential for the design …

Plasmodium vivax Duffy Binding Protein (PvDBP) is the most promising vaccine candidate
for P. vivax malaria. The polymorphic nature of PvDBP induces strain-specific immune …

Abstract The Plasmodium vivax Duffy-binding protein (DBP) is a prime target of the
protective immune response and a promising vaccine candidate for P. vivax malaria …

Background Knowledge of the diversity of invasion ligands in malaria parasites in endemic
regions is essential to understand how natural selection influences genetic diversity of these …

The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this
parasite must invade immature red blood cells through a process requiring interaction of the …

Plasmodium vivax is the geographically most widespread human malaria parasite. To
analyze patterns of microsatellite diversity and population structure across countries of …

Background The Plasmodium vivax Apical Membrane Antigen 1 (Pv AMA1) is a promising
malaria vaccine candidate, however it remains unclear which regions are naturally targeted …

Background A major concern in malaria vaccine development is genetic polymorphisms
typically observed among Plasmodium isolates in different geographical areas across the …