Inherited and age-related retinal degeneration is the hallmark of a large group of
heterogeneous diseases and is the main cause of untreatable blindness today. Genetic …

Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

Retinopathy of prematurity (ROP) is an important cause of childhood blindness globally, and
the incidence is rising. The disease is characterized by initial arrested retinal vascularization …

Purpose Our objective was to comprehensively assess the nature and chronology of neural
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …

Müller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of
functional interactions between neurons and Müller cells, including delivery of the light …

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine
fashion to affect vital cellular processes such as proliferation, differentiation, and …

Norrin is a secreted protein that binds to frizzled 4 and controls development of capillaries in
retina and inner ear. We provide evidence that Norrin has distinct neuroprotective properties …

Survival and death of photoreceptors in degenerative diseases of the retina is controlled by
a multitude of genes and endogenous factors. Some genes may be involved in the …