The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

The catabolic process of macroautophagy, through the rapid degradation of unwanted
cellular components, is involved in a multitude of cellular and organismal functions that are …

Combinatorial CRISPR-Cas screens have advanced the mapping of genetic interactions,
but their experimental scale limits the number of targetable gene combinations. Here, we …

Multisystem proteinopathy (MSP) is a pleiotropic group of inherited disorders that cause
neurodegeneration, myopathy, and bone disease, and share common pathophysiology …

At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Paget's disease of bone (PDB) is the second most prevalent metabolic bone disorder
worldwide, with a prevalence rate of 1.5%–8.3%. It is characterized by localized areas of …

Abstract Purpose of Review The purpose of this review is to recognize clinical features of
Paget's disease of bone and to describe how the osteoclast, a myeloid-derived cell …

Abnormally increased resorption contributes to bone degenerative diseases such as Paget's
disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene …

In recent years, the study of single nucleotide polymorphisms (SNPs) has gained increasing
importance in biomedical research, as they can either be at the molecular origin of a …

Autophagy is a highly conserved lysosomal degradation pathway responsible for rapid
elimination of unwanted cytoplasmic materials in response to stressful conditions. This …