Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …

Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

Since ancient times, plants have been an extensive reservoir of bioactive compounds with
therapeutic interest for new drug development and clinical application. Cucurbitacins are a …

Abstract In Chinese medicine, the Cucurbitaceae family contains many compounds known
as cucurbitacins, which have been categorized into 12 classes ranging from A to T and more …

Cancer is one of the most important healthcare matters, with the worst prognosis but the best
possibilities for scientific development. It is likely to increase in the future and cause global …

Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

STATs constitute a large family of transcription activators and transducers of signals that
have an important role in many cell functions as regulation of proliferation and differentiation …