Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …

Alzheimer's disease (AD) represents arguably the most significant social, economic, and
medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is …

Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …

Cell replacement therapies for neurodegenerative disease have focused on transplantation
of the cell types affected by the pathological process. Here we describe an alternative …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that
two small molecules (forskolin and dorsomorphin) enable the transcription factor …

Human neurodegenrative diseases such as P arkinson's disease (PD), H untington's
disease (HD), amyotrophic lateral sclerosis (ALS) and A lzheimer's disease (AD) are caused …