Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral
blood flow. Emerging evidence implicates astrocytes as one of the key players in …

Flavonoids and nitrates in fruits and vegetables may protect against cardiovascular disease.
Dietary flavonoids and nitrates can augment nitric oxide status via distinct pathways, which …

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

K+ channels are widely distributed in both plant and animal cells where they serve many
distinct functions. K+ channels set the membrane potential, generate electrical signals in …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

Diabetes and hypertension are the leading causes of chronic kidney disease and their
incidence is increasing at an alarming rate. Both are associated with impairments in the …

Abstract Cytochrome P450s (P450) metabolize arachidonic acid (AA) to
hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs). Among these …