Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the …

Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

Parthanatos-associated apoptosis-inducing factor (AIF) nuclease (PAAN), also known as
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …

Macrophages and microglia can be polarized along a continuum toward a detrimental (M1)
or a beneficial (M2) state in the injured CNS. Although phagocytosis of myelin in vitro …

The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by
data showing that common functional polymorphisms in MIF are associated with disease …

Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

Glucocorticoids are the most effective anti-inflammatory therapy for many chronic
inflammatory and immune diseases, such as asthma, but are relatively ineffective in other …

Introduction. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …

Abdominal obesity is a major risk factor for cardiovascular disease, and recent studies
highlight a key role of adipose tissue dysfunction, inflammation, and aberrant adipokine …