[HTML][HTML] COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Perioperative pulmonary atelectasis: part I. Biology and mechanisms

C Zeng, D Lagier, JW Lee, MF Vidal Melo - Anesthesiology, 2022 - pubs.asahq.org
Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced
when collapsing forces derived from positive pleural pressure and surface tension overcome …

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

K Westphalen, GA Gusarova, MN Islam… - Nature, 2014 - nature.com
The tissue-resident macrophages of barrier organs constitute the first line of defence against
pathogens at the systemic interface with the ambient environment. In the lung, resident …

Thoughts on the alveolar phase of COVID-19

RJ Mason - American Journal of Physiology-Lung Cellular …, 2020 - journals.physiology.org
COVID-19 can be divided into three clinical stages, and one can speculate that these stages
correlate with where the infection resides. For the asymptomatic phase, the infection mostly …

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

S Herold, NM Gabrielli, I Vadász - American Journal of …, 2013 - journals.physiology.org
In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

N Sommer, I Strielkov, O Pak… - European Respiratory …, 2016 - Eur Respiratory Soc
Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler–Liljestrand
mechanism, is an essential response of the pulmonary vasculature to acute and sustained …

Endothelial and smooth muscle cell interactions in the pathobiology of pulmonary hypertension

Y Gao, T Chen, JU Raj - American Journal of Respiratory Cell and …, 2016 - atsjournals.org
In the pulmonary vasculature, the endothelial and smooth muscle cells are two key cell types
that play a major role in the pathobiology of pulmonary vascular disease and pulmonary …

Hypoxic pulmonary vasoconstriction

ER Swenson - High altitude medicine & biology, 2013 - liebertpub.com
Abstract Swenson, Erik R. Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14: 101–
110, 2013.—Hypoxic pulmonary vasoconstriction (HPV) continues to fascinate …

The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease

I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …