Infections at the maternal–fetal interface: an overview of pathogenesis and defence
CJ Megli, CB Coyne - Nature Reviews Microbiology, 2022 - nature.com
Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …
[HTML][HTML] Significance of the placental barrier in antenatal viral infections
The placenta provides a significant physical and physiological barrier to prevent fetal
infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to …
infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to …
Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta
Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes
formed by maternal endometrial caruncles and fetal placental cotyledons and required for …
formed by maternal endometrial caruncles and fetal placental cotyledons and required for …
Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface
L Yang, EC Semmes, C Ovies, C Megli, S Permar… - Elife, 2022 - elifesciences.org
Infections at the maternal-fetal interface can directly harm the fetus and induce complications
that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived …
that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived …
Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion
A Ozmen, O Guzeloglu-Kayisli, S Tabak… - Frontiers in cell and …, 2022 - frontiersin.org
Among several interleukin (IL)-6 family members, only IL-6 and IL-11 require a gp130
protein homodimer for intracellular signaling due to lack of intracellular signaling domain in …
protein homodimer for intracellular signaling due to lack of intracellular signaling domain in …
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua
The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome
remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify …
remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify …
Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta
G Borges-Vélez, JA Arroyo, YM Cantres-Rosario… - Cells, 2022 - mdpi.com
Zika virus (ZIKV) compromises placental integrity, infecting the fetus. However, the
mechanisms associated with ZIKV penetration into the placenta leading to fetal infection are …
mechanisms associated with ZIKV penetration into the placenta leading to fetal infection are …
GAS6-mediated dialogue between decidual stromal cells and macrophages is essential for early pregnancy maintenance by inducing M2-like polarization and cell …
JC Dai, JY Yang, RQ Chang, Y Liang… - Molecular Human …, 2022 - academic.oup.com
Maternal immunotolerance towards the semi-allogeneic foetus is critical for normal
pregnancy (NP). As a secretory protein, growth arrest-specific factor 6 (GAS6) promotes …
pregnancy (NP). As a secretory protein, growth arrest-specific factor 6 (GAS6) promotes …
Interferon lambda signals in maternal tissues to exert protective and pathogenic effects in a gestational stage-dependent manner
ABSTRACT Interferon lambda (IFN-λ)(type III IFN) is constitutively secreted from human
placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice …
placental cells in culture and reduces Zika virus (ZIKV) transplacental transmission in mice …
Regulation of proinflammatory molecules and tissue factor by SARS-CoV-2 spike protein in human placental cells: implications for SARS-CoV-2 pathogenesis in …
X Guo, N Semerci, V De Assis, UA Kayisli… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 infects cells via binding to ACE2 and TMPRSS2, which allows the virus to fuse
with host cells. The viral RNA is detected in the placenta of SARS-CoV-2-infected pregnant …
with host cells. The viral RNA is detected in the placenta of SARS-CoV-2-infected pregnant …