IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …

Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …

Common variable immunodeficiency (CVID) is the most common symptomatic primary
antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM …

The development of increasingly efficient and cost-effective high throughput DNA
sequencing techniques has enhanced the possibility of studying complex microbial systems …

The relationship between metabolic and inflammatory pathways play a pathogenic role in
various cardiometabolic disorders and is potentially also involved in the pathogenesis of …

Introduction Besides recurrent infections, a proportion of patients with Common Variable
Immunodeficiency Disorders (CVID) may suffer from immune dysregulation such as …

Bacterial respiratory tract infections are the hallmark of primary antibody deficiencies
(PADs). Because they are also among the most common infections in healthy individuals …

Purpose Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL)
appear to be related to inflammation. Patients with common variable immunodeficiency …

Background Mycoplasma pneumoniae is a common cause of community-acquired
pneumonia in school-aged children and can be preceded by asymptomatic carriage …

Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous
disorder with inadequate antibody responses and low levels of immunoglobulins including …