Inflammation orchestrates each stage of the life cycle of atherosclerotic plaques. Indeed,
inflammatory mediators likely link many traditional and emerging risk factors with …

The vascular inflammatory response involves complex interaction between inflammatory
cells (neutrophils, lymphocytes, monocytes, macrophages), endothelial cells (ECs), vascular …

Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause
of mortality worldwide. Proteases have been implicated in the development and progression …

intracellularly, making it ideally suited to modify signaling pathways and gene expression.
The activity of the NAD (P) H oxidases can be modulated by vasoactive hormones and the …

Epidemiologic studies have demonstrated an association between increased intake of
antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality …

Rupture of atherosclerotic plaque has been identified as the proximate event in the majority
of cases of acute ischemic syndromes. Plaque rupture exposes thrombogenic components …

Background—Several recent studies attempted to classify plaques as those prone to cause
clinical manifestations (vulnerable, atheromatous plaques) or those less frequently …

Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …

Objective—Inflammation plays an important role in atherosclerosis. One of the most potent
pro-inflammatory cytokines is tumor necrosis factor-α (TNF-α), a cytokine identified to have a …

Rheumatoid arthritis (RA) is associated with excess morbidity and mortality from myocardial
infarction and allied disorders. A large body of evidence supports the involvement of …