The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …

Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic
heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has …

Sepsis occurs due to a damaging host response to infection and is the chief cause of death
in most intensive care units. Mesenchymal stem cells (MSCs) exhibit immunomodulatory …

Although chemotherapeutic agents have been used for decades, the mechanisms of action,
mechanisms of resistance, and the best treatment schedule remain elusive. Mitomycin C …

As the leading cause of cancer death, cervical cancer ranks fourth for both incidence and
mortality. Cervical cancer incidence and mortality rates have reportedly decreased over the …

Obesity induces multifactorial effects such as dyslipidemia, insulin resistance, and arterial
hypertension that influence the progression of many diseases. Obesity is associated with an …

Background Colorectal cancer (CRC) is one of the most common cancers worldwide.
Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been confirmed to be …

Lipid metabolism in cancer cells has garnered increasing attention in recent decades.
Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and …

The paradigm of drug delivery via particulate formulations is one of the leading ideas that
enable overcoming limitations of traditional chemotherapeutic agents. The trend toward …

Abstract Background Circular RNAs (circRNAs) have been discovered to participate in the
carcinogenesis of multiple cancers. However, the role of circRNAs in esophageal squamous …