Classification of intrinsically disordered regions and proteins

R Van Der Lee, M Buljan, B Lang, RJ Weatheritt… - Chemical …, 2014 - ACS Publications
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Intrinsically disordered proteins and intrinsically disordered protein regions

CJ Oldfield, AK Dunker - Annual review of biochemistry, 2014 - annualreviews.org
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)

FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy

MR Jensen, M Zweckstetter, J Huang… - Chemical …, 2014 - ACS Publications
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …

Bacterial osmoregulation: a paradigm for the study of cellular homeostasis

JM Wood - Annual review of microbiology, 2011 - annualreviews.org
To thrive, cells must control their own physical and chemical properties. This process is
known as cellular homeostasis. The dilute solutions traditionally favored by experimenters …

Crowding in cellular environments at an atomistic level from computer simulations

M Feig, I Yu, P Wang, G Nawrocki… - The Journal of Physical …, 2017 - ACS Publications
The effects of crowding in biological environments on biomolecular structure, dynamics, and
function remain not well understood. Computer simulations of atomistic models of …

Describing intrinsically disordered proteins at atomic resolution by NMR

MR Jensen, RWH Ruigrok, M Blackledge - Current opinion in structural …, 2013 - Elsevier
There is growing interest in the development of physical methods to study the
conformational behaviour and biological activity of intrinsically disordered proteins (IDPs). In …

Cisplatin binding to proteins: A structural perspective

L Messori, A Merlino - Coordination Chemistry Reviews, 2016 - Elsevier
The interactions of clinically established anticancer Pt-based drugs with proteins play crucial
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …

Introduction to intrinsically disordered proteins (IDPs)

VN Uversky - Chemical reviews, 2014 - ACS Publications
For more than a century, molecular and structural biology, biochemistry, and protein
biophysics have been dominated by a “rigid” or “semi-rigid” view of a functional protein …

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?

A Binolfi, FX Theillet, P Selenko - Biochemical Society …, 2012 - portlandpress.com
The notion that human α-synuclein is an intrinsically disordered monomeric protein was
recently challenged by a postulated α-helical tetramer as the physiologically relevant protein …