The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

Genome-wide analyses of the eukaryotic transcriptome have revealed that the majority of
the genome is transcribed, producing large numbers of non-protein-coding RNAs (ncRNAs) …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

Leishmania donovani is an intracellular protozoan parasite that causes kala-azar in
humans. During infection the extracellular insect forms (promastigotes) undergo rapid …

The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are
transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal …

Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist.
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …

Simple Summary Successful gene therapy mainly depends on the fabrication of efficient and
nontoxic carriers that can compact genetic materials and adequately deliver them to target …

The fate of Leishmania infection can be strongly influenced by the host genetic background.
In this work, we describe gene expression modulation of the immune system based on dual …