Hypophosphatasia (HPP) results from ALPL mutations leading to deficient activity of the
tissue-non-specific alkaline phosphatase isozyme (TNAP) and thereby extracellular …

The importance of matrix vesicles (MVs) has been repeatedly highlighted in the formation of
cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures …

Background: Recent evidence suggests that bone-related parameters are the main
prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated …

Bone mineralization is initiated by matrix vesicles, small extracellular vesicles secreted by
osteoblasts, inducing the nucleation and subsequent growth of calcium phosphate crystals …

The lack of effective strategies to produce vascularized 3D bone transplants in vitro,
hampers the development of thick-constructed bone, limiting the translational of lab-based …

Cardiovascular calcification (CVC) is associated with increased morbidity and mortality. It
develops in several diseases and locations, such as in the tunica intima in atherosclerosis …

Given that alkaline phosphatase (ALP) is an important biomarker for many diseases,
monitoring of its activity turns to be of great significance for related disease diagnosis and …

Craniofacial anomalies are among the most common of birth defects. The pathogenesis of
craniofacial anomalies frequently involves defects in the migration, proliferation, and fate of …

Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the
subject of an increasing focus of research. This work has elucidated PHOSPHO1's central …

As alkaline phosphatase (ALP) plays crucial roles in disease warning and
dephosphorylation-related cellular regulation, it is widely recognized as an important …