An updated evolutionary classification of CRISPR–Cas systems
KS Makarova, YI Wolf, OS Alkhnbashi… - Nature reviews …, 2015 - nature.com
The evolution of CRISPR–cas loci, which encode adaptive immune systems in archaea and
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
Bacteria–phage coevolution as a driver of ecological and evolutionary processes in microbial communities
B Koskella, MA Brockhurst - FEMS microbiology reviews, 2014 - academic.oup.com
Bacteria–phage coevolution, the reciprocal evolution between bacterial hosts and the
phages that infect them, is an important driver of ecological and evolutionary processes in …
phages that infect them, is an important driver of ecological and evolutionary processes in …
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
The ability to artificially control transcription is essential both to the study of gene function
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Annotation and classification of CRISPR-Cas systems
KS Makarova, EV Koonin - CRISPR: methods and protocols, 2015 - Springer
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
[PDF][PDF] CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity
R Barrangou, LA Marraffini - Molecular cell, 2014 - cell.com
Clustered regularly interspaced short palindromic repeats (CRISPR), and associated
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
The crystal structure of Cpf1 in complex with CRISPR RNA
D Dong, K Ren, X Qiu, J Zheng, M Guo, X Guan, H Liu… - Nature, 2016 - nature.com
The CRISPR–Cas systems, as exemplified by CRISPR–Cas9, are RNA-guided adaptive
immune systems used by bacteria and archaea to defend against viral infection,,,,,,. The …
immune systems used by bacteria and archaea to defend against viral infection,,,,,,. The …
[HTML][HTML] CRISPRDetect: a flexible algorithm to define CRISPR arrays
Background CRISPR (clustered regularly interspaced short palindromic repeats) RNAs
provide the specificity for noncoding RNA-guided adaptive immune defence systems in …
provide the specificity for noncoding RNA-guided adaptive immune defence systems in …
CRISPR-mediated adaptive immune systems in bacteria and archaea
R Sorek, CM Lawrence… - Annual review of …, 2013 - annualreviews.org
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …