Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …

Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …

Circular RNAs are a large group of noncoding RNAs that are widely expressed in
mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily …

The intestinal epithelium forms a barrier protecting the organism from microbes and other
proinflammatory stimuli. The integrity of this barrier and the proper response to infection …

Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to
prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect …

Colorectal cancer (CRC) is the third most diagnosed cancer worldwide and the second
leading cause of cancer‐related deaths. Many researchers have reported that abnormal …

Abstract A recent International Diabetes Federation report suggests that more than 463
million people between 20 and 79 years have diabetes. Of the 20 million women affected by …

Circular RNAs (circRNAs) are single-stranded and covalently closed back-splicing products
of pre-mRNAs. They can be derived from exons, introns, or exons with intron retained …

Dnmt1 is critical for immediate postnatal intestinal development, but is not required for the
survival of the adult intestinal epithelium, the only rapidly dividing somatic tissue for which …

Cells encounter a multitude of external and internal stress-causing agents that can ultimately
lead to DNA damage, mutations and disease. A cascade of signaling events counters these …