Molecular docking studies applied to a dataset of cruzain inhibitors
EF da Silva-Junior, PH Barcellos Franca… - … -Aided Drug Design, 2018 - ingentaconnect.com
Background: Chagas' disease is one of the main causes of heart failure in developing
countries. The disadvantages of current therapy include the undesirable side-effects …
countries. The disadvantages of current therapy include the undesirable side-effects …
Computer-assisted evaluation of plant-derived β-secretase inhibitors in Alzheimer's disease
Background Alzheimer's disease (AD) is a progressive neurodegenerative age-related
dementia that results in memory loss of elderly people. Many hypotheses have been …
dementia that results in memory loss of elderly people. Many hypotheses have been …
In silico molecular docking study to search new SGLT2 inhibitor based on dioxabicyclo [3.2. 1] octane scaffold
Background: Diabetes is a leading cause of high mortality rate in the world. Recently, SGLT2
inhibitors showed the promising result to treat diabetes and therefore several molecules are …
inhibitors showed the promising result to treat diabetes and therefore several molecules are …
Kamonolol acetate from Ferula pseudalliacea as AChE inhibitor: in vitro and in silico studies
Alzheimer's disease is one of the most common causes of dementia. Acetylcholinesterase
has been considered as the main therapeutic target in the treatment of Alzheimer's disease …
has been considered as the main therapeutic target in the treatment of Alzheimer's disease …
Morelloflavone as a novel inhibitor of mitotic kinesin Eg5
TH Ogunwa, K Taii, K Sadakane… - The journal of …, 2019 - academic.oup.com
Among 40 plant-derived biflavonoids with inhibitory potential against Eg5, morelloflavone
from Garcinia dulcis leaves was selected for further testing based on in silico analysis of …
from Garcinia dulcis leaves was selected for further testing based on in silico analysis of …
1, 2, 4 Triazoles and 1, 2, 4 Oxadiazoles Scaffold as SGLT2 Inhibitors: Molecular Docking and ADMET Studies
S Sharma, A Mittal - Letters in Drug Design & Discovery, 2023 - ingentaconnect.com
Background: Diabetes mellitus (DM) is a metabolic disorder in which blood sugar levels are
elevated over a prolonged period of time. SGLT2 inhibitors have recently demonstrated …
elevated over a prolonged period of time. SGLT2 inhibitors have recently demonstrated …
The potential of natural product vs neurodegenerative disorders: In silico study of artoflavanocoumarin as BACE-1 inhibitor
N Razzaghi-Asl, A Karimi, A Ebadi - Computational biology and chemistry, 2018 - Elsevier
Increasing evidence suggests the beneficial impact of flavonoid-rich nutrition on normal
cognitive function. It has been revealed that flavonoids can slow neurodegenerative …
cognitive function. It has been revealed that flavonoids can slow neurodegenerative …
Chimgin from Ferula haussknechtii as AChE inhibitor and confirmation of the absolute configuration
Alzheimer's disease (AD) is the most common cause of dementia worldwide and is classified
as a neurodegenerative disorder. From a drug design perspective, natural products (NPs) …
as a neurodegenerative disorder. From a drug design perspective, natural products (NPs) …
Modeling of BACE-1 Inhibitors as Anti-Alzheimer's Agents
TQ Froes, DB Barbosa, MR do Bomfim… - … Modeling of Drugs …, 2023 - Springer
Since BACE-1's role in Alzheimer's disease (AD) etiology was elucidated, inhibitors of this
enzyme have been pursued as primary targets for the treatment of this ailment. Despite …
enzyme have been pursued as primary targets for the treatment of this ailment. Despite …
Molecular dynamics simulation of privileged biflavonoids as SARS-CoV2 3CLpro targeting agents
T Vahabzadeh, M Miran… - Journal of Computational …, 2022 - World Scientific
According to the limited medications for COVID-19, natural products gained increasing
attention. Scientific indications revealed the effect of biflavonoids (BFs) against respiratory …
attention. Scientific indications revealed the effect of biflavonoids (BFs) against respiratory …