Antioxidants play a crucial role in the protection and maintenance of health and are also
integral ingredients in beauty products. The active antioxidants possess numerous …

Local anesthetics, which cause temporary loss of pain by inhibiting the transmission of nerve
impulses, have been widely used in clinical practice. However, neurotoxicity and short half …

Local anesthetics are a class of drugs, which have wide applications in the treatment of
acute and chronic pain. However, their analgesic effects only last for a few hours because of …

From a clinical perspective, local anesthetics have rather widespread application in regional
blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer …

Peripheral nerve blockade (PNB) is a conventional strategy for the management of acute
postoperative pain. However, the short duration of the associated analgesia and the …

Topical delivery of local anesthetics (LAs) is commonly used to decrease painful sensations,
block pain throughout procedures, and alleviate pain after surgery. Dermal and/or …

Objective To investigate the effect of formulation parameters on the preparation of
transfersomes as sustained-release delivery systems for lidocaine and to develop and …

Extended-release local anesthetics (LAs) have drawn increasing attention with their
promising role in improving analgesia and reducing adverse events of LAs. Nano-structured …

Safe and efficient local anesthetic delivery carriers are crucial for long-term anesthesia and
analgesics in clinical treatment. But currently, most of the local anesthetic carriers still have …

Autophagy allows cancer cells to respond changes in nutrient status by degrading and
recycling non-essential intracellular contents. Inhibition of autophagy combined with nutrient …