Reactivity of metal–oxo clusters towards biomolecules: from discrete polyoxometalates to metal–organic frameworks

DES Marcano, ND Savić, K Declerck… - Chemical Society …, 2023 - pubs.rsc.org
Metal–oxo clusters hold great potential in several fields such as catalysis, materials science,
energy storage, medicine, and biotechnology. These nanoclusters of transition metals with …

Impact of host cell line choice on glycan profile

JB Goh, SK Ng - Critical reviews in biotechnology, 2018 - Taylor & Francis
Protein glycosylation is post-translational modification (PTM) which is important for
pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result …

Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues

S Holst, B Heijs, N De Haan, RJM Van Zeijl… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging is a rapidly
evolving field in which mass spectrometry techniques are applied directly on tissues to …

Glycan engagement by viruses: receptor switches and specificity

LJ Ströh, T Stehle - Annual review of virology, 2014 - annualreviews.org
A large number of viruses, including many human pathogens, bind cell-surface glycans
during the initial steps of infection. Viral glycan receptors such as glycosaminoglycans and …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010

DJ Harvey - Mass spectrometry reviews, 2015 - Wiley Online Library
This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

ZIC-cHILIC-based stageTip for simultaneous glycopeptide enrichment and fractionation toward large-scale N-sialoglycoproteomics

YJ Chen, TC Yen, YH Lin, YL Chen, KH Khoo… - Analytical …, 2021 - ACS Publications
Alterations of protein glycosylation are closely related with pathophysiological regulation.
Due to the structural macro-and microheterogeneity, low stoichiometry, and low ionization …

Online hydrophilic interaction chromatography (HILIC) enhanced top-down mass spectrometry characterization of the SARS-CoV-2 spike receptor-binding domain

JW Wilson, A Bilbao, J Wang, YC Liao… - Analytical …, 2022 - ACS Publications
SARS-CoV-2 cellular infection is mediated by the heavily glycosylated spike protein.
Recombinant versions of the spike protein and the receptor-binding domain (RBD) are …

Aberrant sialylation in ovarian cancers

WL Lee, PH Wang - Journal of the Chinese Medical Association, 2020 - journals.lww.com
Sialylation (the covalent addition of sialic acid to the terminal end of glycoproteins or
glycans), tightly regulated cell-and microenvironment-specific process and orchestrated by …

Structural analysis of glycoprotein sialylation–part II: LC-MS based detection

G Palmisano, MR Larsen, NH Packer… - Rsc Advances, 2013 - pubs.rsc.org
Structural characterisation of sialylated glycoproteins in time and space is a requirement for
further understanding of their involvement in biology. In this second of two related reviews …

Polysialic acid in the immune system

TM Villanueva-Cabello… - Frontiers in …, 2022 - frontiersin.org
Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …