New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The evolution of genome mining in microbes–a review

N Ziemert, M Alanjary, T Weber - Natural product reports, 2016 - pubs.rsc.org
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

JC Frisvad, V Hubka, CN Ezekiel, SB Hong… - Studies in …, 2019 - ingentaconnect.com
Aflatoxins and ochratoxins are among the most important mycotoxins of all and producers of
both types of mycotoxins are present in Aspergillus section Flavi, albeit never in the same …

Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Biologically active secondary metabolites from the fungi

GF Bills, JB Gloer - Microbiology spectrum, 2016 - Am Soc Microbiol
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

[HTML][HTML] The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production

T Weber, HU Kim - Synthetic and Systems Biotechnology, 2016 - Elsevier
Natural products are among the most important sources of lead molecules for drug
discovery. With the development of affordable whole-genome sequencing technologies and …

Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals

B Sandargo, C Chepkirui, T Cheng… - Biotechnology …, 2019 - Elsevier
The Basidiomycota constitutes the second largest higher taxonomic group of the Fungi after
the Ascomycota and comprises over 30.000 species. Mycelial cultures of Basidiomycota …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …