The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
Regulation of microRNA biogenesis
M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology
Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25
nucleotides) that negatively control expression of target genes at the post-transcriptional …
nucleotides) that negatively control expression of target genes at the post-transcriptional …
Self-protected DNAzyme walker with a circular bulging DNA shield for amplified imaging of miRNAs in living cells and mice
Y Gao, S Zhang, C Wu, Q Li, Z Shen, Y Lu, ZS Wu - ACS nano, 2021 - ACS Publications
Abnormal expression of miRNAs is often detected in various human cancers. DNAzyme
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
machines combined with gold nanoparticles (AuNPs) hold promise for detecting specific …
Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations
Chromosomal translocations encode oncogenic fusion proteins that have been proven to be
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …
Clinical relevance of circulating cell-free microRNAs in cancer
H Schwarzenbach, N Nishida, GA Calin… - Nature reviews Clinical …, 2014 - nature.com
Efficient patient management relies on early diagnosis of disease and monitoring of
treatment. In this regard, much effort has been made to find informative, blood-based …
treatment. In this regard, much effort has been made to find informative, blood-based …
MicroRNA: function, detection, and bioanalysis
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
Cancer genetics and epigenetics: two sides of the same coin?
JS You, PA Jones - Cancer cell, 2012 - cell.com
Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …
MicroRNAs in stress signaling and human disease
JT Mendell, EN Olson - Cell, 2012 - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …