Surgical management of Crohn disease in children: guidelines from the Paediatric IBD Porto Group of ESPGHAN

J Amil-Dias, S Kolacek, D Turner… - Journal of pediatric …, 2017 - journals.lww.com
The incidence of Crohn disease (CD) has been increasing and surgery needs to be
contemplated in a substantial number of cases. The relevant advent of biological treatment …

[HTML][HTML] Personalising medicine in inflammatory bowel disease—current and future perspectives

JJ Ashton, E Mossotto, S Ennis… - Translational …, 2019 - ncbi.nlm.nih.gov
Up to 25% of inflammatory bowel disease (IBD) presents during childhood, often with severe
and extensive disease, leading to significant morbidity including delayed growth and …

The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery

NA Afratis, M Klepfish, NK Karamanos, I Sagi - Advanced drug delivery …, 2018 - Elsevier
Progressive loss of organ function in most organs is associated with fibrosis, a tissue state
associated with abnormal matrix buildup. If highly progressive, the fibrotic process …

Early-onset paediatric inflammatory bowel disease

JJ Ashton, S Ennis, RM Beattie - The Lancet Child & Adolescent …, 2017 - thelancet.com
The incidence of early-onset paediatric inflammatory bowel disease is increasing worldwide.
Defined as a diagnosis of Crohn's disease, ulcerative colitis, or inflammatory bowel disease …

Surgery and postoperative recurrence in children with Crohn disease

LF Hansen, C Jakobsen, A Paerregaard… - Journal of pediatric …, 2015 - journals.lww.com
Objectives: The aim of this study was to describe surgery rates, complications, and risk of
disease recurrence after surgery in paediatric Crohn disease (CD). Methods: Children< 18 …

Surgery for children with Crohn's disease: indications, complications and outcome

SC Blackburn, AE Wiskin, C Barnes, K Dick… - Archives of disease in …, 2014 - adc.bmj.com
Background Outcome data for surgery in paediatric Crohn's disease are limited. We report
10 years' experience at a regional paediatric gastroenterology centre. Methods Children …

NASPGHAN clinical report on postoperative recurrence in pediatric Crohn disease

JB Splawski, MD Pffefferkorn… - Journal of pediatric …, 2017 - journals.lww.com
Pediatric Crohn disease is characterized by clinical and endoscopic relapses. The
inflammatory process is considered to be progressive and may lead to strictures, fistulas …

Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents

M Hukkinen, MP Pakarinen, L Merras-Salmio… - Journal of pediatric …, 2016 - Elsevier
Background Fecal calprotectin (FC) correlates with endoscopic recurrence of Crohn's
disease (CD) in adults but has not been studied among children postoperatively. We aimed …

The pharmacotherapeutic management of pediatric Crohn's disease

L Zimmerman, A Bousvaros - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
Introduction: Crohn's disease (CD) is a chronic inflammatory condition that can occur
throughout the gastrointestinal tract. The aims of treatment of children with CD are to induce …

Long-term outcomes after elective ileocecal resection in children with active localized Crohn's disease—a multicenter European study

I Hojsak, S Kolacek, LF Hansen, J Bronsky… - Journal of pediatric …, 2015 - Elsevier
Purpose The aim of this study was to investigate the therapeutic role of an elective ileocecal
resection in children with active localized Crohn's disease. Methods This was a retrospective …