Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are
caused by abnormal responses to relatively harmless foreign proteins called allergens …

Abstract Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and
elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the …

Conventional dendritic cells (cDCs) can integrate multiple stimuli from the environment and
provide three separate outputs in terms of antigen presentation, costimulation, and cytokine …

Adaptive CD4+ T helper cells and their innate counterparts, innate lymphoid cells, utilize an
identical set of transcription factors (TFs) for their differentiation and functions. However …

Highlights•Distinct stages of antimycobacterial IFN-γ immunity revealed by studies of IEI of
TFs.•Interleukin (IL)-12 and IL-23, produced by myeloid cells, enhance IFN-γ production.•IFN …

Type 2 immunity is activated in response to both allergens and helminth infection. It can be
detrimental or beneficial, and there is a pressing need to better understand its regulation …