The ins and outs of innate and adaptive type 2 immunity
AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
T helper cell subsets: diversification of the field
CE Zielinski - European journal of immunology, 2023 - Wiley Online Library
Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …
Human inborn errors of immunity: 2022 update on the classification from the international union of immunological societies expert committee
SG Tangye, W Al-Herz, A Bousfiha… - Journal of clinical …, 2022 - Springer
We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …
International Union of Immunological Societies Expert Committee. This report documents the …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
Understanding the development of Th2 cell-driven allergic airway disease in early life
B León - Frontiers in Allergy, 2023 - frontiersin.org
Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are
caused by abnormal responses to relatively harmless foreign proteins called allergens …
caused by abnormal responses to relatively harmless foreign proteins called allergens …
IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
H Bachus, E McLaughlin, C Lewis… - Cellular & Molecular …, 2023 - nature.com
Abstract Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and
elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the …
elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the …
A model of Th2 differentiation based on polarizing cytokine repression
B León - Trends in immunology, 2023 - cell.com
Conventional dendritic cells (cDCs) can integrate multiple stimuli from the environment and
provide three separate outputs in terms of antigen presentation, costimulation, and cytokine …
provide three separate outputs in terms of antigen presentation, costimulation, and cytokine …
Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation
Adaptive CD4+ T helper cells and their innate counterparts, innate lymphoid cells, utilize an
identical set of transcription factors (TFs) for their differentiation and functions. However …
identical set of transcription factors (TFs) for their differentiation and functions. However …
[HTML][HTML] Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity
Highlights•Distinct stages of antimycobacterial IFN-γ immunity revealed by studies of IEI of
TFs.•Interleukin (IL)-12 and IL-23, produced by myeloid cells, enhance IFN-γ production.•IFN …
TFs.•Interleukin (IL)-12 and IL-23, produced by myeloid cells, enhance IFN-γ production.•IFN …
Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response
HC Webster, V Gamino, AT Andrusaite… - Mucosal …, 2022 - nature.com
Type 2 immunity is activated in response to both allergens and helminth infection. It can be
detrimental or beneficial, and there is a pressing need to better understand its regulation …
detrimental or beneficial, and there is a pressing need to better understand its regulation …