The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the
world. It is a complicated pathological process that consists of primary insults and a …

Mitochondrial permeability transition pore (mPTP) plays a central role in alterations of
mitochondrial structure and function leading to neuronal injury relevant to aging and …

Mutations in mitochondrial DNA (mtDNA) associate with various disease states. A few
mtDNA mutations strongly associate with diabetes, with the most common mutation being …

The kinetic properties for the uptake, storage and release of Ca2+ from isolated
mitochondria accurately predict the behaviour of the organelles within the intact cell. While …

Autophagy is a novel response of cancer cells to ionizing radiation (IR) or chemotherapy, but
its significance or mechanism remains largely elusive. Autophagy is characterized with the …

Amyloid beta (Aβ) plays a critical role in the pathophysiology of Alzheimer's disease.
Increasing evidence indicates mitochondria as an important target of Aβ toxicity; however …

Axonal degeneration is an active process that has been associated with neurodegenerative
conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory …