TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Molecular physiology of TRPV channels: controversies and future challenges
T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …
molecules that allow the detection of such signals include ion channels, which are proteins …
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
A Neuberger, YA Trofimov, MV Yelshanskaya… - Nature …, 2023 - nature.com
The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in
human cancers. Despite increasing interest of pharmacological research in developing …
human cancers. Despite increasing interest of pharmacological research in developing …
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6
inhibitors are needed for the treatment of a broad range of diseases associated with …
inhibitors are needed for the treatment of a broad range of diseases associated with …
Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein
A Neuberger, YA Trofimov, MV Yelshanskaya… - Nature …, 2023 - nature.com
Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human
cancers. While significant effort has been invested in the development of synthetic TRPV6 …
cancers. While significant effort has been invested in the development of synthetic TRPV6 …
Ligand-binding sites in vanilloid-subtype TRP channels
MV Yelshanskaya, AI Sobolevsky - Frontiers in Pharmacology, 2022 - frontiersin.org
Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological
processes and are implicated in numerous human diseases. Advances in structural biology …
processes and are implicated in numerous human diseases. Advances in structural biology …
[HTML][HTML] Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here,
we combine calcium imaging and patch-clamp electrophysiology with cryo-electron …
we combine calcium imaging and patch-clamp electrophysiology with cryo-electron …
TRPV3: Structure, diseases and modulators
W Su, X Qiao, W Wang, S He, K Liang, X Hong - Molecules, 2023 - mdpi.com
Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor
potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can …
potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can …
Calcium selective channel TRPV6: Structure, function, and implications in health and disease
Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …
Inactivation-mimicking block of the epithelial calcium channel TRPV6
R Bhardwaj, S Lindinger, A Neuberger… - Science …, 2020 - science.org
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its
dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the …
dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the …