The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Basal autophagy is a crucial mechanism in cellular homeostasis, underlying both normal
cellular recycling and the clearance of damaged or misfolded proteins, organelles and …

The incidence and prevalence of cardiac diseases, which are the main cause of death
worldwide, are likely to increase because of population ageing. Prevailing theories about …

Myofibrillar myopathies (MFMs) represent a group of muscular dystrophies with a similar
morphological phenotype. The diagnosis is established by muscle biopsy. The MFMs are …

During the past two decades, numerous disease-causing genes for different
cardiomyopathies have been identified. These discoveries have led to better understanding …

Rationale: Increasing evidence suggests that misfolded proteins and intracellular
aggregates contribute to cardiac disease and heart failure. Several cardiomyopathies …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

Proteinopathy causes cardiac disease, remodeling, and heart failure but the pathological
mechanisms remain obscure. Mutated αB-crystallin (CryABR120G), when expressed only in …

Since proteins play crucial roles in all biological processes, the finely tuned equilibrium
between their synthesis and degradation regulates cellular homeostasis. Controlling the …