Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal
function. Accordingly, transformation and cancer progression are characterized by dramatic …

We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C)
that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme …

Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …

The liver fluke remains an economically significant parasite of livestock and is emerging as
an important zoonotic infection of humans. The incidence of the disease has increased in …

Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted
through the food chain, four of which are recognized as neglected tropical diseases (NTDs) …

The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following
ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge …

Fasciolosis caused by Fasciola hepatica severely affects the efficiency of livestock
production systems worldwide. In addition to the economic impact inflicted on livestock …

Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Cathepsin L is an important cysteine protease, but its function in T. spiralis remains unclear.
The aim of this research was to explore the biological characteristics of T. spiralis cathepsin …

Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …